E3 ubiquitin-protein ligase CHFR is an enzyme that in humans is encoded by the CHFR gene.[5][6][7]

CHFR
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCHFR, RNF116, RNF196, checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase, checkpoint with forkhead and ring finger domains
External IDsOMIM: 605209; MGI: 2444898; HomoloGene: 10078; GeneCards: CHFR; OMA:CHFR - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018223
NM_001161344
NM_001161345
NM_001161346
NM_001161347

NM_001289577
NM_001289578
NM_001289579
NM_001289580
NM_172717

RefSeq (protein)

NP_001154816
NP_001154817
NP_001154818
NP_001154819
NP_060693

NP_001276506
NP_001276507
NP_001276508
NP_001276509
NP_766305

Location (UCSC)Chr 12: 132.82 – 132.96 MbChr 5: 110.28 – 110.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CHFR is recruited to sites of DNA damage and participates in the DNA damage response. CHFR has an important role in the survival of male premeiotic germ cells.[8] About 30% of male CHFR knockout mice are infertile.[8] In these knockout mice spermatogenesis onset is delayed and apoptosis in premeiotic germ cells is significantly increased. When these mice are 3 months old there is a complete loss of germ cells in their testes.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000072609Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000014668Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Scolnick DM, Halazonetis TD (Aug 2000). "Chfr defines a mitotic stress checkpoint that delays entry into metaphase". Nature. 406 (6794): 430–5. Bibcode:2000Natur.406..430S. doi:10.1038/35019108. PMID 10935642. S2CID 4401185.
  6. ^ Kang D, Chen J, Wong J, Fang G (Jan 2002). "The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition". J Cell Biol. 156 (2): 249–59. doi:10.1083/jcb.200108016. PMC 2199220. PMID 11807090.
  7. ^ "Entrez Gene: CHFR checkpoint with forkhead and ring finger domains". YouTube.
  8. ^ a b Lu LY, Yu X (2015). "CHFR is important for the survival of male premeiotic germ cells". Cell Cycle. 14 (21): 3454–3460. doi:10.1080/15384101.2015.1093701. PMC 4825563. PMID 26566864.
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Further reading

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