Centrosomal protein 170kDa, also known as CEP170, is a protein that in humans is encoded by the CEP170 gene.[5][6]

CEP170
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCEP170, FAM68A, KAB, KIAA0470, centrosomal protein 170
External IDsOMIM: 613023; MGI: 1918348; HomoloGene: 22844; GeneCards: CEP170; OMA:CEP170 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001042404
NM_001042405
NM_014812

NM_001024722
NM_001099637
NM_001368872
NM_001368873

RefSeq (protein)

NP_001035863
NP_001035864
NP_055627

NP_001093107
NP_001355801
NP_001355802

Location (UCSC)Chr 1: 243.12 – 243.26 MbChr 1: 176.56 – 176.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with the intraflagellar transport protein 81 (IFT81), the SH3-domain containing protein PRAX-1, and is phosphorylated by cyclin dependent kinase 1 (Cdk1) and polo-like kinase 1 (PLK1), and functions in maintaining microtubule organization, cell morphology and cilium stability.[5]

The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined.[5]

References

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  1. ^ a b c ENSG00000276725 GRCh38: Ensembl release 89: ENSG00000143702, ENSG00000276725Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057335Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c "Entrez Gene: CEP170 centrosomal protein 170kDa".
  6. ^ Guarguaglini G, Duncan PI, Stierhof YD, Holmström T, Duensing S, Nigg EA (March 2005). "The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles". Molecular Biology of the Cell. 16 (3): 1095–107. doi:10.1091/mbc.E04-10-0939. PMC 551476. PMID 15616186.
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  • Human CEP170 genome location and CEP170 gene details page in the UCSC Genome Browser.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Centrosomal protein of 170 kDa (CEP170)

Further reading

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