CENPI

Centromere protein I is a protein that in humans is encoded by the CENPI gene.

CENPI
Identifiers
Aliases	CENPI, CENP-I, FSHPRH1, LRPR1, Mis6, centromere protein I
External IDs	OMIM: 300065; MGI: 2147897; HomoloGene: 4899; GeneCards: CENPI; OMA:CENPI - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xq22.1 Start 101,098,188 bp End 101,166,126 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X E3 Start 133,208,833 bp End 133,263,388 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte ventricular zone gonad ganglionic eminence testicle stromal cell of endometrium smooth muscle tissue bone marrow rectum trabecular bone Top expressed in hand tail of embryo dermis genital tubercle otic vesicle abdominal wall endothelial cell of lymphatic vessel ventricular zone renal corpuscle spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component chromosome chromosome, centromeric region nucleoplasm kinetochore nucleus cytosol nuclear body Biological process sex differentiation centromere complex assembly CENP-A containing chromatin assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2491 102920 Ensembl ENSG00000102384 ENSMUSG00000031262 UniProt Q92674 Q8K1K4 RefSeq (mRNA) NM_006733 NM_001318521 NM_001318523 NM_001386188 NM_145924 NM_001305631 RefSeq (protein) NP_001305450 NP_001305452 NP_006724 NP_001292560 NP_666036 Location (UCSC) Chr X: 101.1 – 101.17 Mb Chr X: 133.21 – 133.26 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. This gene is also a potential candidate for human X-linked disorders of gonadal development and gametogenesis. CENPI is a target gene of the transcription factor E2F. Additionally, CENPI expression is increased in breast cancer and this has been shown to cause chromosome instability in breast cancer cells.

Further reading

• Izuta H, Ikeno M, Suzuki N, Tomonaga T, Nozaki N, Obuse C, Kisu Y, Goshima N, Nomura F, Nomura N, Yoda K (June 2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes to Cells. 11 (6): 673–84. doi:10.1111/j.1365-2443.2006.00969.x. PMID 16716197.
• Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nature Cell Biology. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419. S2CID 205286556.
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (February 2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes to Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
• Liu ST, Hittle JC, Jablonski SA, Campbell MS, Yoda K, Yen TJ (April 2003). "Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis". Nature Cell Biology. 5 (4): 341–5. doi:10.1038/ncb953. PMID 12640463. S2CID 33165992.
• Roberts RG, Kendall E, Vetrie D, Bobrow M (October 1996). "Sequence and chromosomal location of a human homologue of LRPR1, an FSH primary response gene". Genomics. 37 (1): 122–4. doi:10.1006/geno.1996.0528. PMID 8921378.
• Slegtenhorst-Eegdeman KE, Post M, Baarends WM, Themmen AP, Grootegoed JA (February 1995). "Regulation of gene expression in Sertoli cells by follicle-stimulating hormone (FSH): cloning and characterization of LRPR1, a primary response gene encoding a leucine-rich protein". Molecular and Cellular Endocrinology. 108 (1–2): 115–24. doi:10.1016/0303-7207(94)03468-9. hdl:1765/64471. PMID 7758824. S2CID 11122437.
• Adams MD, Dubnick M, Kerlavage AR, Moreno R, Kelley JM, Utterback TR, Nagle JW, Fields C, Venter JC (February 1992). "Sequence identification of 2,375 human brain genes". Nature. 355 (6361): 632–4. Bibcode:1992Natur.355..632A. doi:10.1038/355632a0. PMID 1538749. S2CID 4234345.

External links

• Human CENPI genome location and CENPI gene details page in the UCSC Genome Browser.