Cadherin-4 is a protein that in humans is encoded by the CDH4 gene.[5][6][7]

CDH4
Identifiers
AliasesCDH4, CAD4, R-CAD, RCAD, cadherin 4
External IDsOMIM: 603006; MGI: 99218; HomoloGene: 48044; GeneCards: CDH4; OMA:CDH4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001794
NM_001252338
NM_001252339

NM_009867
NM_001316723

RefSeq (protein)

NP_001239267
NP_001239268
NP_001785

NP_001303652
NP_033997

Location (UCSC)Chr 20: 61.25 – 61.94 MbChr 2: 179.08 – 179.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization.[7]

Interactions

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Cadherin-4 has been shown to interact with:

References

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  1. ^ a b c ENSG00000179242 GRCh38: Ensembl release 89: ENSG00000280641, ENSG00000179242Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000305Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chalmers IJ, Hofler H, Atkinson MJ (Jun 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics. 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID 10191097.
  6. ^ Kools P, Vanhalst K, van Roy F (Oct 1999). "Assignment of cadherin-4 (R-cadherin, CDH4) to human chromosome band 20q13.3". Cytogenet Cell Genet. 86 (1): 26–7. doi:10.1159/000015423. PMID 10516427. S2CID 27578498.
  7. ^ a b "Entrez Gene: CDH4 cadherin 4, type 1, R-cadherin (retinal)".
  8. ^ Brady-Kalnay SM, Mourton T, Nixon JP, Pietz GE, Kinch M, Chen H, et al. (1998). "Dynamic interaction of PTPmu with multiple cadherins in vivo". J Cell Biol. 141 (1): 287–96. doi:10.1083/jcb.141.1.287. PMC 2132733. PMID 9531566.

Further reading

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