CCAR1

Cell division cycle and apoptosis regulator protein 1 is a protein that in humans is encoded by the CCAR1 gene.

CCAR1
Identifiers
Aliases	CCAR1, cell division cycle and apoptosis regulator 1
External IDs	OMIM: 612569; MGI: 1914750; HomoloGene: 10086; GeneCards: CCAR1; OMA:CCAR1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q21.3 Start 68,721,012 bp End 68,792,377 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 B4 Start 62,579,707 bp End 62,628,065 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm pancreatic ductal cell visceral pleura parietal pleura ventricular zone sural nerve pylorus Achilles tendon ganglionic eminence seminal vesicula Top expressed in genital tubercle tail of embryo Rostral migratory stream human fetus ciliary body migratory enteric neural crest cell maxillary prominence abdominal wall pineal gland mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding transcription corepressor activity nuclear receptor coactivator activity transcription coactivator activity RNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component cytoplasm perinuclear region of cytoplasm nucleoplasm nucleus Biological process positive regulation of cell migration mRNA splicing, via spliceosome cell cycle regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of cell population proliferation apoptotic process negative regulation of nucleic acid-templated transcription positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55749 67500 Ensembl ENSG00000060339 ENSMUSG00000020074 UniProt Q8IX12 Q8CH18 RefSeq (mRNA) NM_001282959 NM_001282960 NM_018237 NM_026201 RefSeq (protein) NP_001269888 NP_001269889 NP_060707 NP_080477 Location (UCSC) Chr 10: 68.72 – 68.79 Mb Chr 10: 62.58 – 62.63 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

External links

• Human CCAR1 genome location and CCAR1 gene details page in the UCSC Genome Browser.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• McDonald ER, El-Deiry WS (2004). "Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth". Proc. Natl. Acad. Sci. U.S.A. 101 (16): 6170–5. Bibcode:2004PNAS..101.6170M. doi:10.1073/pnas.0307459101. PMC 395941. PMID 15069192.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rishi AK, Zhang L, Yu Y, et al. (2006). "Cell cycle- and apoptosis-regulatory protein-1 is involved in apoptosis signaling by epidermal growth factor receptor". J. Biol. Chem. 281 (19): 13188–98. doi:10.1074/jbc.M512279200. PMID 16543231.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Zhang L, Levi E, Majumder P, et al. (2007). "Transactivator of transcription-tagged cell cycle and apoptosis regulatory protein-1 peptides suppress the growth of human breast cancer cells in vitro and in vivo". Mol. Cancer Ther. 6 (5): 1661–72. doi:10.1158/1535-7163.MCT-06-0653. PMID 17513614.