C81 or C-81 may refer to :
- C81 (album) (1981)
- C-81 (Michigan county highway)
- C-81 Reliant, a 1933 military aircraft
- Campbell Airport's FAA LID code
- Hodgkin's lymphoma's ICD-10 code
- NGC 6352's Caldwell catalog number
- Ruy Lopez's Encyclopaedia of Chess Openings code
This disambiguation page lists articles associated with the same title formed as a letter–number combination.
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