Bronidox, or 5-bromo-5-nitro-1,3-dioxane, is an antimicrobial chemical compound.
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Names | |
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Preferred IUPAC name
5-Bromo-5-nitro-1,3-dioxane | |
Other names
5-Bromo-5-nitro-m-dioxane
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Identifiers | |
3D model (JSmol)
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ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.045.441 |
EC Number |
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PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C4H6BrNO4 | |
Molar mass | 211.999 g·mol−1 |
Appearance | White crystalline powder |
Melting point | 60 °C (140 °F; 333 K)[1] 58.5−62 °C[2] |
insoluble | |
Hazards | |
GHS labelling: | |
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Danger | |
H302, H314, H315, H317, H410 | |
P260, P261, P264, P270, P272, P273, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P330, P332+P313, P333+P313, P362, P363, P391, P405, P501 | |
Lethal dose or concentration (LD, LC): | |
LD50 (median dose)
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590 mg/kg (mouse, oral) 455 mg/kg (rat, oral) 31 mg/kg (rat, ipr.) 2500 μg (mouse, skin) 2500 μg (rat, skin) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Bronidox causes inhibition of enzyme activity in bacteria.[3]
Bronidox is corrosive to metals.[4]
Uses
edit- Bactericide
- Fungicide, effective against yeast and other fungi[citation needed]
- It is used in immunology for preserving antibodies and antisera in 0.1 - 0.5% concentration. It is used as preservative to avoid use of sodium azide.
- Stabilizer
- Surfactant
- Used in cosmetics since the mid-1970s as preservative for shampoos, foam bath, etc. Maximum concentration is 0.1%.
- Some users do not recommend use in preparations destined for in vivo or tissue culture work[5]
See also
editReferences
edit- ^ 5-BROMO-5-NITRO-1,3-DIOXANE Archived March 3, 2016, at the Wayback Machine, chemicalland21.com
- ^ "Bronidox, Product Information Sheet" (PDF). Archived from the original (PDF) on September 29, 2007. Retrieved March 19, 2006.
- ^ Ghannoum M, Thomson M, Bowman W, Al-Khalil S (1986). "Mode of action of the antimicrobial compound 5-bromo-5-nitro-1,3-dioxane (bronidox)". Folia Microbiol. (Praha). 31 (1): 19–31. doi:10.1007/BF02928676. PMID 3082729. S2CID 23920602.
- ^ http://www.products.cognis.com/COGNIS/prodleaf.nsf/(SBU_Catalog)/FFAD30C61B67EFEB41256B4100427DD1/$File/BRONIDOX_r_L_5_E.pdf [dead link]
- ^ [1] Archived December 21, 2004, at the Wayback Machine