Brignoni, an Italian family name, can refer to:
- Jonas Brignoni Dos Santos (1983–), a Brazilian footballer
- Luis Brignoni (1953–), a Puerto Rican basketballer
- Nicolas Brignoni (1976–), a former Uruguayan rugby union player
- Serge Brignoni (1903–2002), a Swiss painter and sculptor
- United States v. Brignoni-Ponce, a 1975 court case