Big Four Depot may refer to:
- Lafayette, Indiana (Amtrak station), listed on the NRHP in Indiana as "Big Four Depot"
- Big Four Depot (Delaware, Ohio), in operation to 1965
- Big Four Depot (Galion, Ohio), listed on the NRHP in Ohio
- Big Four Depot (Middletown, Ohio), listed on the NRHP in Ohio
- Big Four Depot (Springfield, Ohio), in operation to 1969
- Big Four Depot (Terre Haute, Indiana), more recently an Amtrak station
This disambiguation page lists articles associated with the title Big Four Depot.
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