In enzymology, a benzyl-2-methyl-hydroxybutyrate dehydrogenase (EC 1.1.1.217) is an enzyme that catalyzes the chemical reaction
| benzyl-2-methyl-hydroxybutyrate dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.217 | ||||||||
| CAS no. | 99332-62-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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- benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP+ benzyl 2-methyl-3-oxobutanoate + NADPH + H+
Thus, the two substrates of this enzyme are benzyl (2R,3S)-2-methyl-3-hydroxybutanoate and NADP+, whereas its 3 products are benzyl 2-methyl-3-oxobutanoate, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is benzyl-(2R,3S)-2-methyl-3-hydroxybutanoate:NADP+ 3-oxidoreductase. This enzyme is also called benzyl 2-methyl-3-hydroxybutyrate dehydrogenase.
References
edit- Furuichi A, Akita H, Matsukura H, Oishi T, Horikoshi K (1985). "Purification and properties of an asymmetric reduction enzyme of 2-methyl-3-oxobutyrate in baker's yeast". Agric. Biol. Chem. 49 (9): 2563–2570. doi:10.1271/bbb1961.49.2563.
