Batanopride (BMY-25,801) is an antiemetic drug of the benzamide class which acts as a selective 5-HT3 receptor antagonist.[1] It was trialled to reduce nausea during cancer chemotherapy, but was never approved for medical use due to dose-limiting side effects including hypotension and long QT syndrome.[2]
Clinical data | |
---|---|
Routes of administration | Oral |
ATC code |
|
Legal status | |
Legal status |
|
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
ChEMBL | |
Chemical and physical data | |
Formula | C17H26ClN3O3 |
Molar mass | 355.86 g·mol−1 |
3D model (JSmol) | |
| |
| |
(what is this?) (verify) |
References edit
- ^ Gylys JA, Wright RN, Nicolosi WD, Buyniski JP, Crenshaw RR (March 1988). "BMY-25801, an antiemetic agent free of D2-dopamine receptor antagonist properties". The Journal of Pharmacology and Experimental Therapeutics. 244 (3): 830–7. PMID 2978041.
- ^ Fleming GF, Vokes EE, McEvilly JM, Janisch L, Francher D, Smaldone L (1991). "Double-blind, randomized crossover study of metoclopramide and batanopride for prevention of cisplatin-induced emesis". Cancer Chemotherapy and Pharmacology. 28 (3): 226–7. doi:10.1007/bf00685516. PMID 1855280. S2CID 22520773.