Basso is an Italian surname. Notable people with the surname include:
- Adriano Basso, Brazilian footballer
- Aina Basso, Norwegian historian and novelist
- Annalise Basso (born 1998), American actress
- Anthony Basso, French footballer
- Claudio Basso (born 1977), Argentine singer
- Dominick Basso (1938–2001), mobster in the Chicago Outfit
- Flávio Basso (1968–2015), Brazilian musician
- Gabriel Basso (born 1994), American actor
- Giandomenico Basso, Italian rally driver
- Girolamo Basso della Rovere (1434–1507), Italian Cardinal of the Roman Catholic Church
- Guido Basso (1937–2023), jazz musician from Montreal
- Hamilton Basso (1904 – 1964), American novelist
- Ivan Basso, Italian cyclist
- Jorge Basso (born 1956), Uruguayan physician and politician
- Josias Basso, Brazilian footballer
- Keith H. Basso (1940–2013), American anthropologist
- Lelio Basso (1903 – 1978), Italian politician and journalist
- Leonardo Basso, Italian cyclist
- Marino Basso, Italian cyclist
- Oscar Basso (1922–2007), Argentine professional football player
- Romina Basso, Italian mezzo-soprano
- Sonia Basso (born 1954), Italian cross-country skier
- Stephen Basso (born 1987), Costa Rican-born American soccer player
- Suzanne Basso (1954–2014), American convicted murderer
- Tom Basso, American financier and trader
- Basso, pseudonym of Natsume Ono (born 1977), Japanese manga artist