BRCA1-associated ATM activator 1 is a protein in humans that is encoded by the BRAT1 gene.[5]

BRAT1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBRAT1, BAAT1, C7orf27, RMFSL, BRCA1 associated ATM activator 1, NEDCAS
External IDsOMIM: 614506; MGI: 1891679; HomoloGene: 16776; GeneCards: BRAT1; OMA:BRAT1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_152743
NM_001350626
NM_001350627

NM_001276287
NM_172724
NM_181066

RefSeq (protein)

NP_689956
NP_001337555
NP_001337556

NP_001263216
NP_851411

Location (UCSC)Chr 7: 2.54 – 2.56 MbChr 5: 140.69 – 140.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106009Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000148Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: BRCA1-associated ATM activator 1".
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  • Human BRAT1 genome location and BRAT1 gene details page in the UCSC Genome Browser.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human BRCA1-associated ATM activator