Transcription factor TFIIIB component B″ homolog also known as TFIIIB150 is a protein that in humans is encoded by the BDP1 gene.[5][6][7]

BDP1
Identifiers
AliasesBDP1, HSA238520, TAF3B1, TFC5, TFIIIB150, TFIIIB90, TFNR, B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB, DFNB112, TFIIIB''
External IDsOMIM: 607012; MGI: 1347077; HomoloGene: 34582; GeneCards: BDP1; OMA:BDP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018429

NM_001081061

RefSeq (protein)

NP_060899

NP_001074530

Location (UCSC)Chr 5: 71.46 – 71.57 MbChr 13: 100.02 – 100.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

edit

TFIIIB150 is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase 2 during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription.[7]

References

edit
  1. ^ a b c ENSG00000273873, ENSG00000145734 GRCh38: Ensembl release 89: ENSG00000274803, ENSG00000273873, ENSG00000145734Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049658Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
  6. ^ Schramm L, Pendergrast PS, Sun Y, Hernandez N (Nov 2000). "Different human TFIIIB activities direct RNA polymerase III transcription from TATA-containing and TATA-less promoters". Genes Dev. 14 (20): 2650–63. doi:10.1101/gad.836400. PMC 316990. PMID 11040218.
  7. ^ a b "Entrez Gene: BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB".

Further reading

edit
edit