BDP1

Transcription factor TFIIIB component B″ homolog also known as TFIIIB150 is a protein that in humans is encoded by the BDP1 gene.

BDP1
Identifiers
Aliases	BDP1, HSA238520, TAF3B1, TFC5, TFIIIB150, TFIIIB90, TFNR, B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB, DFNB112, TFIIIB''
External IDs	OMIM: 607012 MGI: 1347077 HomoloGene: 34582 GeneCards: BDP1
Gene location (Human) Chr. Chromosome 5 (human) Band 5q13.2 Start 71,455,651 bp End 71,567,820 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13 D1|13 52.92 cM Start 100,017,994 bp End 100,104,070 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve Achilles tendon corpus callosum right uterine tube thymus bone marrow cells endometrium superior frontal gyrus ganglionic eminence cerebellar cortex Top expressed in superior cervical ganglion hand otolith organ utricle cumulus cell primitive streak medullary collecting duct condyle fossa hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding TFIIIC-class transcription factor complex binding RNA polymerase III general transcription initiation factor activity Cellular component nucleus transcription factor TFIIIB complex nucleoplasm Biological process regulation of transcription by RNA polymerase III regulation of transcription, DNA-templated transcription, DNA-templated RNA polymerase III preinitiation complex assembly transcription by RNA polymerase III Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55814 544971 Ensembl ENSG00000274803 ENSG00000273873 ENSG00000145734 ENSMUSG00000049658 UniProt A6H8Y1 H7C5U4 Q571C7 RefSeq (mRNA) NM_018429 NM_001081061 RefSeq (protein) NP_060899 NP_001074530 Location (UCSC) Chr 5: 71.46 – 71.57 Mb Chr 13: 100.02 – 100.1 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

TFIIIB150 is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase 2 during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription.

Further reading

• Chu WM, Wang Z, Roeder RG, Schmid CW (1997). "RNA polymerase III transcription repressed by Rb through its interactions with TFIIIB and TFIIIC2". J. Biol. Chem. 272 (23): 14755–61. doi:10.1074/jbc.272.23.14755. PMID 9169441.
• Wang Z, Roeder RG (1997). "Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation". Genes Dev. 11 (10): 1315–26. doi:10.1101/gad.11.10.1315. PMID 9171375.
• Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
• Kelter AR, Herchenbach J, Wirth B (2001). "The transcription factor-like nuclear regulator (TFNR) contains a novel 55-amino-acid motif repeated nine times and maps closely to SMN1". Genomics. 70 (3): 315–26. doi:10.1006/geno.2000.6396. PMID 11161782.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hu P, Wu S, Hernandez N (2003). "A minimal RNA polymerase III transcription system from human cells reveals positive and negative regulatory roles for CK2". Mol. Cell. 12 (3): 699–709. doi:10.1016/j.molcel.2003.08.011. PMID 14527415.
• Fairley JA, Scott PH, White RJ (2003). "TFIIIB is phosphorylated, disrupted and selectively released from tRNA promoters during mitosis in vivo". EMBO J. 22 (21): 5841–50. doi:10.1093/emboj/cdg544. PMC 275401. PMID 14592981.
• Weser S, Gruber C, Hafner HM, et al. (2004). "Transcription factor (TF)-like nuclear regulator, the 250-kDa form of Homo sapiens TFIIIB", is an essential component of human TFIIIC1 activity". J. Biol. Chem. 279 (26): 27022–9. doi:10.1074/jbc.M312790200. PMID 15096501.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Hu P, Samudre K, Wu S, et al. (2004). "CK2 phosphorylation of Bdp1 executes cell cycle-specific RNA polymerase III transcription repression". Mol. Cell. 16 (1): 81–92. doi:10.1016/j.molcel.2004.09.008. PMID 15469824.
• Schoenen F, Wirth B (2006). "The zinc finger protein ZNF297B interacts with BDP1, a subunit of TFIIIB". Biol. Chem. 387 (3): 277–84. doi:10.1515/BC.2006.037. PMID 16542149. S2CID 28560128.
• Johnson SS, Zhang C, Fromm J, et al. (2007). "Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases". Mol. Cell. 26 (3): 367–79. doi:10.1016/j.molcel.2007.03.021. PMID 17499043.

External links

• FactorBook BDP1
• Human BDP1 genome location and BDP1 gene details page in the UCSC Genome Browser.