In enzymology, an aryl-acylamidase (EC 3.5.1.13) is an enzyme that catalyzes the chemical reaction

aryl-acylamidase
Identifiers
EC no.3.5.1.13
CAS no.9025-18-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
an anilide + H2O a carboxylate + aniline

Thus, the two substrates of this enzyme are anilide and H2O, whereas its two products are carboxylate and aniline.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is aryl-acylamide amidohydrolase. Other names in common use include AAA-1, AAA-2, brain acetylcholinesterase (is associated with AAA-2), and pseudocholinesterase (associated with arylacylamidase).

References

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  • Nimmo-Smith RH (May 1960). "Aromatic N-deacylation by chick-kidney mitochondria". The Biochemical Journal. 75 (2): 284–93. PMC 1204423. PMID 14427286.