In molecular biology, members of the ArgJ protein family are bifunctional protein that catalyses the first (EC 2.3.1.35) and fifth steps (EC 2.3.1.1) in arginine biosynthesis.[1] The structure has been determined for glutamate N-acetyltransferase 2 (ornithine acetyltransferase), an ArgJ-like protein from Streptomyces clavuligerus.[2]
| ArgJ | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 ornithine acetyltransferase (orf6 gene product - clavulanic acid biosynthesis) from streptomyces clavuligerus | |||||||||
| Identifiers | |||||||||
| Symbol | ArgJ | ||||||||
| Pfam | PF01960 | ||||||||
| InterPro | IPR002813 | ||||||||
| CDD | cd02152 | ||||||||
| |||||||||
References
edit- ^ Sakanyan V, Charlier D, Legrain C, Kochikyan A, Mett I, Pierard A, Glansdorff N (March 1993). "Primary structure, partial purification and regulation of key enzymes of the acetyl cycle of arginine biosynthesis in Bacillus stearothermophilus: dual function of ornithine acetyltransferase". J. Gen. Microbiol. 139 (3): 393–402. doi:10.1099/00221287-139-3-393. PMID 8473852.
- ^ Elkins JM, Kershaw NJ, Schofield CJ (January 2005). "X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster". Biochem. J. 385 (Pt 2): 565–73. doi:10.1042/BJ20040814. PMC 1134730. PMID 15352873.