Annexin A6 is a protein that in humans is encoded by the ANXA6 gene.[5]

ANXA6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesANXA6, ANX6, CBP68, annexin A6, CPB-II, p70, p68
External IDsOMIM: 114070; MGI: 88255; HomoloGene: 55558; GeneCards: ANXA6; OMA:ANXA6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001155
NM_001193544
NM_004033
NM_001363114

NM_001110211
NM_013472

RefSeq (protein)

NP_001146
NP_001180473
NP_001350043

NP_001103681
NP_038500

Location (UCSC)Chr 5: 151.1 – 151.16 MbChr 11: 54.87 – 54.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Exon 21 of annexin VI is alternatively spliced, giving rise to two isoforms that differ by a 6-amino acid insertion at the start of the seventh repeat. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis.[6]

Interactions

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ANXA6 has been shown to interact with RAS p21 protein activator 1.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197043Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018340Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Crompton MR, Owens RJ, Totty NF, Moss SE, Waterfield MD, Crumpton MJ (Jan 1988). "Primary structure of the human, membrane-associated Ca2+-binding protein p68 a novel member of a protein family". The EMBO Journal. 7 (1): 21–7. doi:10.1002/j.1460-2075.1988.tb02779.x. PMC 454210. PMID 3258820.
  6. ^ "Entrez Gene: ANXA6 annexin A6".
  7. ^ Chow A, Gawler D (Oct 1999). "Mapping the site of interaction between annexin VI and the p120GAP C2 domain". FEBS Letters. 460 (1): 166–72. doi:10.1016/S0014-5793(99)01336-8. PMID 10571081. S2CID 42114086.

Further reading

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