Anna Komnene or Comnena (Greek: Ἄννα Κομνηνὴ) may refer to:
- Anna Komnene (1 December 1083 – 1153), daughter of Alexios I Komnenos.
- Anna Komnene Angelina (c. 1176 – 1212), Empress of Nicaea
- Anna Komnene Doukaina (d. 4 January 1286), known in French as Agnes, Princess-consort of the Principality of Achaea.
- Anna Megale Komnene (6 April 1357 - after 30 November 1406), Queen consort of Georgia
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