All-trans-phytoene synthase

All-trans-phytoene synthase (EC 2.5.1.99, prephytoene-diphosphate synthase, phytoene synthetase, PSase, geranylgeranyl-diphosphate geranylgeranyltransferase, 15-trans-phytoene synthase) is an enzyme with systematic name geranylgeranyl-diphosphate:geranylgeranyl-diphosphate geranylgeranyltransferase (all-trans-phytoene forming).[1][2] This enzyme catalyses the following chemical reaction

All-trans-phytoene synthase
Identifiers
EC no.2.5.1.99
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins
2 geranylgeranyl diphosphate all-trans-phytoene + 2 diphosphate (overall reaction)
(1a) 2 geranylgeranyl diphosphate diphosphate + prephytoene diphosphate
(1b) prephytoene diphosphate all-trans-phytoene + diphosphate

This enzyme requires Mn2+ for activity.

References

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  1. ^ Gregonis DE, Rilling HC (March 1974). "The stereochemistry of trans-phytoene synthesis. Some observations on lycopersene as a carotene precursor and a mechanism for the synthesis of cis- and trans-phytoene". Biochemistry. 13 (7): 1538–42. doi:10.1021/bi00704a033. PMID 4819767.
  2. ^ Iwata-Reuyl D, Math SK, Desai SB, Poulter CD (March 2003). "Bacterial phytoene synthase: molecular cloning, expression, and characterization of Erwinia herbicola phytoene synthase". Biochemistry. 42 (11): 3359–65. doi:10.1021/bi0206614. PMID 12641468.
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