Akihiro Kusumi (楠見 明弘, Kusumi Akihiro, born October 1952[1]) is a Japanese biologist who proposed an explanation for reduced diffusion speed of lipid and protein molecules in the cell membrane, based on a model of hop diffusion in which lipids are confined to a reduced space, created by a membrane-skeleton-induced compartments. this compartments allow the lipids or proteins freely in a limited region and limiting also the diffusion to other parts of the membrane. Getting to a new compartment is called "hop diffusion" while diffusion in the compartment is allowed by Brownian movement, the compartments of the cell are responsible of the reduced diffusion speed of the lipid or proteins when compared to artificial vesicles.[2]

Akihiro Kusumi
楠見 明弘
BornOctober 1952 (1952-10) (age 71)
NationalityJapanese
Alma materKyoto University
Known forProposing the membrane-skeleton fence model to explain hop diffusion
Scientific career
FieldsBiophysics, Molecular biology
InstitutionsOkinawa Institute of Science and Technology (from 2021)

Citations edit

  • JCB article on "hop diffusion"
  • Paradigm shift of the plasma membrane concept from the two-dimensional continuum fluid to the partitioned fluid: high-speed single-molecule tracking of membrane molecules. Annu. Rev. Biophys. struct. 2005. 34:351-78. doi: 10.1146/annurev.biophys.34.040204.144637. [1]

References edit

  1. ^ a b "平成10年度発足4プロジェクト決定". JSTニュース (in Japanese). 24: 2–5. 1998.
  2. ^ Paradigm shift of the plasma membrane concept from the two-dimensional continuum fluid to the partitioned fluid: high-speed single-molecule tracking of membrane molecules. Annu. Rev. Biophys. struct. 2005. 34:351-78. doi: 10.1146/annurev.biophys.34.040204.144637

External links edit