Acyl-homoserine-lactone acylase (EC 3.5.1.97, acyl-homoserine lactone acylase, AHL-acylase, AiiD, N-acyl-homoserine lactone acylase, PA2385 protein, quorum-quenching AHL acylase, quorum-quenching enzyme, PvdQ, QuiP) is an enzyme with systematic name N-acyl-L-homoserine-lactone amidohydrolase.[1][2] This enzyme functions as a quorum quencher by catalysing the following chemical reaction
| Acyl-homoserine-lactone acylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.5.1.97 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- an N-acyl-L-homoserine lactone + H2O L-homoserine lactone + a carboxylate
Acyl homoserine lactones (AHLs) are produced by a number of bacterial species .
References
edit- ^ Sio CF, Otten LG, Cool RH, Diggle SP, Braun PG, Bos R, Daykin M, Cámara M, Williams P, Quax WJ (March 2006). "Quorum quenching by an N-acyl-homoserine lactone acylase from Pseudomonas aeruginosa PAO1". Infection and Immunity. 74 (3): 1673–82. doi:10.1128/iai.74.3.1673-1682.2006. PMC 1418629. PMID 16495538.
- ^ Lin YH, Xu JL, Hu J, Wang LH, Ong SL, Leadbetter JR, Zhang LH (February 2003). "Acyl-homoserine lactone acylase from Ralstonia strain XJ12B represents a novel and potent class of quorum-quenching enzymes". Molecular Microbiology. 47 (3): 849–60. doi:10.1046/j.1365-2958.2003.03351.x. PMID 12535081.
External links
edit- Acyl-homoserine-lactone+acylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
