Antizyme inhibitor 2 (AzI2) also erroneously known as arginine decarboxylase (ADC) is a protein that in humans is encoded by the AZIN2 gene.[5][6][7] In contrast to initial suggestions,[5] Antizyme inhibitor 2 does not act as arginine decarboxylase (ADC) in mammalian cells [8][9]

AZIN2
Identifiers
AliasesAZIN2, ADC, AZI2, ODC-p, ODC1L, ODCp, AZIB1, antizyme inhibitor 2
External IDsOMIM: 608353; MGI: 2442093; HomoloGene: 62172; GeneCards: AZIN2; OMA:AZIN2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001301841
NM_172875

RefSeq (protein)

NP_001288770
NP_766463

Location (UCSC)Chr 1: 33.08 – 33.12 MbChr 4: 128.82 – 128.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000142920Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028789Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Pitkänen LT, Heiskala M, Andersson LC (October 2001). "Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes". Biochemical and Biophysical Research Communications. 287 (5): 1051–1057. doi:10.1006/bbrc.2001.5703. PMID 11587527.
  6. ^ Zhu MY, Iyo A, Piletz JE, Regunathan S (January 2004). "Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine". Biochimica et Biophysica Acta (BBA) - General Subjects. 1670 (2): 156–164. doi:10.1016/j.bbagen.2003.11.006. PMC 3118518. PMID 14738999.
  7. ^ "Entrez Gene: ADC arginine decarboxylase".
  8. ^ Kanerva K, Mäkitie LT, Pelander A, Heiskala M, Andersson LC (January 2008). "Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase" (PDF). The Biochemical Journal. 409 (1): 187–192. doi:10.1042/BJ20071004. PMID 17900240.
  9. ^ López-Contreras AJ, López-Garcia C, Jiménez-Cervantes C, Cremades A, Peñafiel R (October 2006). "Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity". The Journal of Biological Chemistry. 281 (41): 30896–30906. doi:10.1074/jbc.M602840200. PMID 16916800.

Further reading

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