ATG4D

The human ATG4D gene encodes the protein Autophagy related 4D, cysteine peptidase.

ATG4D
Identifiers
Aliases	ATG4D, APG4-D, APG4D, AUTL4, autophagy related 4D cysteine peptidase, HsAPG4D
External IDs	OMIM: 611340 MGI: 2444308 HomoloGene: 13156 GeneCards: ATG4D
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.2 Start 10,543,895 bp End 10,553,418 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A3 Start 21,176,589 bp End 21,189,068 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum gastrocnemius muscle left ventricle skeletal muscle tissue skin of abdomen blood anterior pituitary kidney bone marrow prefrontal cortex Top expressed in lip temporal muscle duodenum digastric muscle triceps brachii muscle extraocular muscle proximal tubule sternocleidomastoid muscle jejunum esophagus More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase activity cysteine-type peptidase activity hydrolase activity cysteine-type endopeptidase activity Cellular component cytoplasm cytosol mitochondrial matrix mitochondrion Biological process autophagy protein transport autophagy of nucleus C-terminal protein lipidation protein delipidation autophagy of mitochondrion autophagosome assembly proteolysis protein targeting to membrane apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84971 235040 Ensembl ENSG00000130734 ENSMUSG00000002820 UniProt Q86TL0 Q8BGV9 RefSeq (mRNA) NM_001281504 NM_032885 NM_153583 RefSeq (protein) NP_001268433 NP_116274 NP_705811 Location (UCSC) Chr 19: 10.54 – 10.55 Mb Chr 9: 21.18 – 21.19 Mb PubMed search
Wikidata
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Function

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed.

This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

Further reading

• Betin VM, MacVicar TD, Parsons SF, Anstee DJ, Lane JD (April 2012). "A cryptic mitochondrial targeting motif in Atg4D links caspase cleavage with mitochondrial import and oxidative stress". Autophagy. 8 (4): 664–76. doi:10.4161/auto.19227. PMC 3405841. PMID 22441018.
• Betin VM, Lane JD (July 2009). "Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis". Journal of Cell Science. 122 (Pt 14): 2554–66. doi:10.1242/jcs.046250. PMC 2704886. PMID 19549685.
• Mariño G, Uría JA, Puente XS, Quesada V, Bordallo J, López-Otín C (February 2003). "Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy". The Journal of Biological Chemistry. 278 (6): 3671–8. doi:10.1074/jbc.M208247200. PMID 12446702.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.