The human ATG4D gene encodes the protein Autophagy related 4D, cysteine peptidase.[5]

ATG4D
Identifiers
AliasesATG4D, APG4-D, APG4D, AUTL4, autophagy related 4D cysteine peptidase, HsAPG4D
External IDsOMIM: 611340; MGI: 2444308; HomoloGene: 13156; GeneCards: ATG4D; OMA:ATG4D - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001281504
NM_032885

NM_153583

RefSeq (protein)

NP_001268433
NP_116274

NP_705811

Location (UCSC)Chr 19: 10.54 – 10.55 MbChr 9: 21.18 – 21.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed.

This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130734Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002820Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Autophagy related 4D, cysteine peptidase".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.