ASCC3

Activating signal cointegrator 1 complex subunit 3 is a protein that in humans is encoded by the ASCC3 gene.

ASCC3
Identifiers
Aliases	ASCC3, ASC1p200, HELIC1, RNAH, activating signal cointegrator 1 complex subunit 3
External IDs	OMIM: 614217; MGI: 1925237; HomoloGene: 4973; GeneCards: ASCC3; OMA:ASCC3 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q16.3 Start 100,508,194 bp End 100,881,372 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 B3 Start 50,468,765 bp End 50,727,581 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua secondary oocyte Achilles tendon gonad stromal cell of endometrium ventricular zone testicle islet of Langerhans bone marrow cells right coronary artery Top expressed in spermatid tail of embryo gastrula spermatocyte genital tubercle epithelium of small intestine supraoptic nucleus hand ascending aorta submandibular gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding 3'-5' DNA helicase activity protein binding hydrolase activity ATP binding helicase activity nucleic acid binding RNA binding Cellular component intracellular anatomical structure membrane nucleoplasm nucleus cytosol activating signal cointegrator 1 complex nuclear speck cytoplasm Golgi apparatus Biological process DNA dealkylation involved in DNA repair DNA duplex unwinding cell population proliferation regulation of transcription, DNA-templated transcription, DNA-templated cellular response to DNA damage stimulus DNA repair Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10973 77987 Ensembl ENSG00000112249 ENSMUSG00000038774 UniProt Q8N3C0 E9PZJ8 RefSeq (mRNA) NM_001284271 NM_006828 NM_022091 NM_198007 RefSeq (protein) NP_001271200 NP_006819 NP_071374 NP_932124 Location (UCSC) Chr 6: 100.51 – 100.88 Mb Chr 10: 50.47 – 50.73 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

ASCC3 has been shown to interact with RELA, C-jun and Serum response factor.

External links

• Human ASCC3 genome location and ASCC3 gene details page in the UCSC Genome Browser.

Further reading

• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Jung DJ, Sung HS, Goo YW, Lee HM, Park OK, Jung SY, Lim J, Kim HJ, Lee SK, Kim TS, Lee JW, Lee YC (Jul 2002). "Novel transcription coactivator complex containing activating signal cointegrator 1". Molecular and Cellular Biology. 22 (14): 5203–11. doi:10.1128/MCB.22.14.5203-5211.2002. PMC 139772. PMID 12077347.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.