ASB1

Ankyrin repeat and SOCS box protein 1 is a protein that is in humans, encoded by the ASB1 gene.

ASB1
Identifiers
Aliases	ASB1, ASB-1, ankyrin repeat and SOCS box containing 1
External IDs	OMIM: 605758; MGI: 1929735; HomoloGene: 9390; GeneCards: ASB1; OMA:ASB1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q37.3 Start 238,426,742 bp End 238,452,250 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 D|1 46.19 cM Start 91,468,266 bp End 91,487,311 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart C1 segment nucleus accumbens right auricle putamen amygdala left ventricle hypothalamus substantia nigra caudate nucleus Top expressed in blood otolith organ utricle seminiferous tubule lumbar spinal ganglion supraoptic nucleus yolk sac spermatocyte substantia nigra lumbar subsegment of spinal cord More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding ubiquitin protein ligase activity Cellular component cytosol ubiquitin ligase complex Biological process multicellular organism development intracellular signal transduction male genitalia development post-translational protein modification protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51665 65247 Ensembl ENSG00000065802 ENSMUSG00000026311 UniProt Q9Y576 Q9WV74 RefSeq (mRNA) NM_001040445 NM_016114 NM_001330196 NM_001039126 NM_023046 RefSeq (protein) NP_001035535 NP_001317125 NP_001034215 NP_075533 Location (UCSC) Chr 2: 238.43 – 238.45 Mb Chr 1: 91.47 – 91.49 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation.

External links

• Human ASB1 genome location and ASB1 gene details page in the UCSC Genome Browser.

Further reading

• Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kile BT, Metcalf D, Mifsud S, et al. (2001). "Functional analysis of Asb-1 using genetic modification in mice". Mol. Cell. Biol. 21 (18): 6189–97. doi:10.1128/MCB.21.18.6189-6197.2001. PMC 87336. PMID 11509662.
• Kile BT, Viney EM, Willson TA, et al. (2001). "Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4". Gene. 258 (1–2): 31–41. doi:10.1016/S0378-1119(00)00402-9. PMID 11111040.
• Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.