ARPC1A

Actin-related protein 2/3 complex subunit 1A is a protein that in humans is encoded by the ARPC1A gene.

ARPC1A
Identifiers
Aliases	ARPC1A, Arc40, HEL-68, SOP2Hs, SOP2L, HEL-S-307, actin related protein 2/3 complex subunit 1A
External IDs	OMIM: 604220; MGI: 1928896; HomoloGene: 4675; GeneCards: ARPC1A; OMA:ARPC1A - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q22.1 Start 99,325,898 bp End 99,366,262 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 G2 Start 145,020,640 bp End 145,045,571 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon gonad hippocampus proper hypothalamus Brodmann area 9 amygdala substantia nigra body of stomach putamen nucleus accumbens Top expressed in transitional epithelium of urinary bladder olfactory tubercle superior frontal gyrus nucleus accumbens dentate gyrus of hippocampal formation granule cell sciatic nerve islet of Langerhans lip globus pallidus ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding actin filament binding Cellular component cytoplasm cytosol arp2/3 protein complex extracellular exosome cytoskeleton actin cytoskeleton muscle cell projection membrane nucleus site of double-strand break Biological process ephrin receptor signaling pathway regulation of actin filament polymerization actin cytoskeleton organization Fc-gamma receptor signaling pathway involved in phagocytosis Arp2/3 complex-mediated actin nucleation membrane organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10552 56443 Ensembl ENSG00000241685 ENSMUSG00000029621 UniProt Q92747 Q9R0Q6 RefSeq (mRNA) NM_006409 NM_001190996 NM_019767 RefSeq (protein) NP_001177925 NP_006400 NP_062741 Location (UCSC) Chr 7: 99.33 – 99.37 Mb Chr 5: 145.02 – 145.05 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages.

External links

• Human ARPC1A genome location and ARPC1A gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Machesky LM, Reeves E, Wientjes F, et al. (1998). "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins". Biochem. J. 328 (1): 105–12. doi:10.1042/bj3280105. PMC 1218893. PMID 9359840.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.