ARDB also known as Antibiotic Resistance Genes Database is a database that tracks antibiotic resistance genes with information such as mechanism of action, resistance profile, ontology, Clusters of Orthologous Genes (COG) and Conserved Domain Database (CDD) annotations.[1] It also contains links to external databases. The database is also for the identification of new resistance genes. During the creation of ARDB in 2009, there was no comprehensive annotation system available. Thus, ontology terms for resistance profiles and mechanisms of actions were created for ARDB. Other things classified by ontology include drug target modification, drug enzymatic destruction and drug transport.[1] Drug transporters are further subclassified by MFS Efflux pumps, SMR Efflux pumps, ABC Efflux pumps, RND Efflux pumps following conventions outlined in this paper.[2] Currently, ARDB contains resistance information for 13,293 genes, 377 types, 257 antibiotics, 632 genomes, 933 species and 124 genera.
| Content | |
|---|---|
| Description | A database that tracks antibiotic resistance genes. |
| Data types captured | Antibiotic resistance genes |
| Organisms | Bacteria |
| Contact | |
| Primary citation | PMID 18832362 |
| Access | |
| Website | ardb |
| Miscellaneous | |
| Bookmarkable entities | yes |
ARDB is no longer maintained. All ARDB data are in CARD, which the developers now recommend instead.
See also
editReferences
edit- ^ a b Liu, B.; Pop, M. (2009-01-01). "ARDB--Antibiotic Resistance Genes Database". Nucleic Acids Research. 37 (Database): D443–D447. doi:10.1093/nar/gkn656. ISSN 0305-1048. PMC 2686595. PMID 18832362.
- ^ Higgins, Christopher F. (April 2007). "Multiple molecular mechanisms for multidrug resistance transporters". Nature. 446 (7137): 749–757. Bibcode:2007Natur.446..749H. doi:10.1038/nature05630. ISSN 0028-0836. PMID 17429392. S2CID 4414214.