UDP-N-acetylglucosamine transferase subunit ALG13 homolog, also known as asparagine-linked glycosylation 13 homolog, is an enzyme that in humans is encoded by the ALG13 gene.[5][6]

ALG13
Identifiers
AliasesALG13, CDG1S, CXorf45, GLT28D1, MDS031, TDRD13, YGL047W, EIEE36, UDP-N-acetylglucosaminyltransferase subunit, ALG13 UDP-N-acetylglucosaminyltransferase subunit, DEE36
External IDsOMIM: 300776; MGI: 1914824; HomoloGene: 78772; GeneCards: ALG13; OMA:ALG13 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_026247

RefSeq (protein)

NP_080523

Location (UCSC)Chr X: 111.67 – 111.76 MbChr X: 143.1 – 143.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

edit

The protein encoded by this gene is a subunit of a bipartite UDP-N-acetylglucosamine transferase. It heterodimerizes with asparagine-linked glycosylation 14 (ALG14) homolog to form a functional UDP-GlcNAc glycosyltransferase that catalyzes the second sugar addition of the highly conserved oligosaccharide precursor in endoplasmic reticulum N-linked glycosylation.[5][7]

See also

edit

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101901Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041718Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: asparagine-linked glycosylation 13 homolog (S. cerevisiae)".
  6. ^ Gao XD, Tachikawa H, Sato T, Jigami Y, Dean N (October 2005). "Alg14 recruits Alg13 to the cytoplasmic face of the endoplasmic reticulum to form a novel bipartite UDP-N-acetylglucosamine transferase required for the second step of N-linked glycosylation". J. Biol. Chem. 280 (43): 36254–62. doi:10.1074/jbc.M507569200. PMID 16100110.
  7. ^ Averbeck N, Keppler-Ross S, Dean N (October 2007). "Membrane topology of the Alg14 endoplasmic reticulum UDP-GlcNAc transferase subunit". J. Biol. Chem. 282 (40): 29081–8. doi:10.1074/jbc.M704410200. PMID 17686769.

Further reading

edit
edit