Aldo-keto reductase family 1 (AKR1) is a family of aldo-keto reductase enzymes that is involved in steroid metabolism.[1] It includes the AKR1C and AKR1D subgroups, which respectively consist of AKR1C1AKR1C4 and AKR1D1.[1] Together with short-chain dehydrogenase/reductases (SDRs), these enzymes catalyze oxidoreductions, act on the C3, C5, C11, C17 and C20 positions of steroids, and function as 3α-HSDTooltip 3α-Hydroxysteroid dehydrogenases, 3β-HSDsTooltip 3β-Hydroxysteroid dehydrogenases, 5β-reductases, 11β-HSDsTooltip 11β-Hydroxysteroid dehydrogenases, 17β-HSDsTooltip 17β-hydroxysteroid dehydrogenases, and 20α-HSDsTooltip 20α-Hydroxysteroid dehydrogenases, respectively.[1] The AKR1C enzymes act as 3-, 17- and 20-ketosteroid reductases, while AKR1D1 acts as the sole 5β-reductase in humans.[1]

AKR1C1, a member of the AKR1 family.

Members

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AKR1A1; AKR1B1; AKR1B10; AKR1C1; AKR1C2; AKR1C3; AKR1C4; AKR1D1; Others

See also

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References

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  1. ^ a b c d Rižner TL, Penning TM (2014). "Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism". Steroids. 79: 49–63. doi:10.1016/j.steroids.2013.10.012. PMC 3870468. PMID 24189185.