Aldo-keto reductase family 1 (AKR1) is a family of aldo-keto reductase enzymes that is involved in steroid metabolism.[1] It includes the AKR1C and AKR1D subgroups, which respectively consist of AKR1C1–AKR1C4 and AKR1D1.[1] Together with short-chain dehydrogenase/reductases (SDRs), these enzymes catalyze oxidoreductions, act on the C3, C5, C11, C17 and C20 positions of steroids, and function as 3α-HSD , 3β-HSDs , 5β-reductases, 11β-HSDs , 17β-HSDs , and 20α-HSDs , respectively.[1] The AKR1C enzymes act as 3-, 17- and 20-ketosteroid reductases, while AKR1D1 acts as the sole 5β-reductase in humans.[1]
![](http://upload.wikimedia.org/wikipedia/commons/thumb/1/15/Protein_AKR1C1_PDB_1ihi.png/300px-Protein_AKR1C1_PDB_1ihi.png)
Members
editAKR1A1; AKR1B1; AKR1B10; AKR1C1; AKR1C2; AKR1C3; AKR1C4; AKR1D1; Others
See also
editReferences
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