Alcohol dehydrogenase 1C is an enzyme that in humans is encoded by the ADH1C gene.[5]

ADH1C
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesADH1C, ADH3, alcohol dehydrogenase 1C (class I), gamma polypeptide
External IDsOMIM: 103730; MGI: 87921; HomoloGene: 73888; GeneCards: ADH1C; OMA:ADH1C - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000669

NM_007409

RefSeq (protein)

NP_000660

NP_031435

Location (UCSC)Chr 4: 99.34 – 99.35 MbChr 3: 137.97 – 138 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

edit

This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol (beverage alcohol), retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibit high activity for ethanol oxidation and play a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster.[6]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000248144Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074207Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Smith M (Mar 1986). "Genetics of Human Alcohol and Aldehyde Dehydrogenases". Advances in Human Genetics 15. Vol. 15. pp. 249–90. doi:10.1007/978-1-4615-8356-1_5. ISBN 978-1-4615-8358-5. PMID 3006456.
  6. ^ "Entrez Gene: ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide".

Further reading

edit
edit