ADCK5 (aarF domain containing kinase 5) is an enzyme that in humans is encoded by the ADCK5 gene . It is situated on chromosome 8 at the q24.3 location.
Function
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ADCK5 is predicted to possess protein serine/threonine kinase activity and to be an integral component of the membrane.[5]
Genomic context
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The ADCK5 gene is located on chromosome 8q24.3. The genomic sequence spans 20,154 base pairs from 144,373,088 to 144,393,242 on the GRCh38.p14 primary assembly. It consists of 19 exons.[5]
Expression
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ADCK5 is ubiquitously expressed across various human tissues, with notable expression in the duodenum and small intestine, among others.[5]
Clinical significance
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Research indicates that ADCK5 may have therapeutic implications in lung cancer.[6]
References
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^ a b c ENSG00000285451 GRCh38: Ensembl release 89: ENSG00000173137, ENSG00000285451 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022550 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b c https://www.ncbi.nlm.nih.gov/gene/203054 ^ Qiu, M; Li, G; Wang, P; Li, X; Lai, F; Luo, R; Liu, B; Lin, J (1 July 2020). "aarF domain containing kinase 5 gene promotes invasion and migration of lung cancer cells through ADCK5-SOX9-PTTG1 pathway". Experimental cell research . 392 (1): 112002. doi :10.1016/j.yexcr.2020.112002 . PMID 32277958 .
