ACTR1B

Beta-centractin is a protein that in humans is encoded by the ACTR1B gene.

ACTR1B
Identifiers
Aliases	ACTR1B, ARP1B, CTRN2, PC3, ARP1 actin-related protein 1 homolog B, centractin beta, ARP1 actin related protein 1 homolog B, actin related protein 1B
External IDs	OMIM: 605144; MGI: 1917446; HomoloGene: 101541; GeneCards: ACTR1B; OMA:ACTR1B - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q11.2 Start 97,655,939 bp End 97,664,044 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 B Start 36,737,195 bp End 36,753,503 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe right hemisphere of cerebellum prefrontal cortex body of pancreas apex of heart Brodmann area 9 right uterine tube left adrenal cortex right adrenal gland body of uterus Top expressed in superior frontal gyrus neural layer of retina dentate gyrus of hippocampal formation granule cell muscle of thigh yolk sac cerebellar cortex primary visual cortex lip right kidney external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein binding ATP binding cytoskeletal protein-membrane anchor activity Cellular component cytoplasm microtubule cytoskeleton cytosol centrosome extracellular exosome cytoskeleton membrane dynactin complex microtubule organizing center extracellular region secretory granule lumen ficolin-1-rich granule lumen cell cortex region Biological process antigen processing and presentation of exogenous peptide antigen via MHC class II neutrophil degranulation establishment of mitotic spindle orientation nuclear migration along microtubule Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10120 226977 Ensembl ENSG00000115073 ENSMUSG00000037351 UniProt P42025 Q8R5C5 RefSeq (mRNA) NM_005735 NM_146107 RefSeq (protein) NP_005726 NP_666219 Location (UCSC) Chr 2: 97.66 – 97.66 Mb Chr 1: 36.74 – 36.75 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins are of equal length and share 90% amino acid identity. They are present in a constant ratio of approximately 1:15 in the dynactin complex.

Further reading

• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Eckley DM, Schroer TA (2004). "Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1". Mol. Biol. Cell. 14 (7): 2645–54. doi:10.1091/mbc.E03-01-0049. PMC 165665. PMID 12857853.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Adams MD, Dubnick M, Kerlavage AR, et al. (1992). "Sequence identification of 2,375 human brain genes". Nature. 355 (6361): 632–4. Bibcode:1992Natur.355..632A. doi:10.1038/355632a0. PMID 1538749. S2CID 4234345.

External links

• ACTR1B human gene location in the UCSC Genome Browser.
• ACTR1B human gene details in the UCSC Genome Browser.