Peroxisomal acyl-coenzyme A oxidase 3 is an enzyme that in humans is encoded by the ACOX3 gene.[5][6]

ACOX3
Identifiers
AliasesACOX3, acyl-CoA oxidase 3, pristanoyl
External IDsOMIM: 603402; MGI: 1933156; HomoloGene: 37792; GeneCards: ACOX3; OMA:ACOX3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001101667
NM_003501

NM_030721
NM_001357018
NM_001357019
NM_001357020

RefSeq (protein)

NP_109646
NP_001343947
NP_001343948
NP_001343949

Location (UCSC)Chr 4: 8.37 – 8.44 MbChr 5: 35.74 – 35.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Acyl-Coenzyme A oxidase 3 also known as pristanoyl-CoA oxidase (ACOX3) is involved in the desaturation of 2-methyl branched fatty acids in peroxisomes. Unlike the rat homolog, the human gene is expressed in very low amounts in the liver such that its mRNA was undetectable by routine Northern-blot analysis, by immunoblotting for its product, or by enzyme activity measurements. However the human cDNA encoding a 700 amino acid protein with a peroxisomal targeting C-terminal tripeptide S-K-L was isolated and is thought to be expressed under special conditions such as specific developmental stages or in a tissue specific manner in tissues that have not yet been examined.[6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000087008Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029098Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Vanhooren JC, Marynen P, Mannaerts GP, Van Veldhoven PP (Sep 1997). "Evidence for the existence of a pristanoyl-CoA oxidase gene in man". Biochem J. 325 (3): 593–9. doi:10.1042/bj3250593. PMC 1218600. PMID 9271077.
  6. ^ a b "Entrez Gene: ACOX3 acyl-Coenzyme A oxidase 3, pristanoyl".

Further reading

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