Multidrug resistance-associated protein 5 is a protein that in humans is encoded by the ABCC5 gene.[5][6][7]

ABCC5
Identifiers
AliasesABCC5, ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11, ATP binding cassette subfamily C member 5
External IDsOMIM: 605251; MGI: 1351644; HomoloGene: 21164; GeneCards: ABCC5; OMA:ABCC5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001023587
NM_005688
NM_001320032

NM_013790
NM_176839

RefSeq (protein)

NP_001018881
NP_001306961
NP_005679

NP_038818
NP_789809

Location (UCSC)Chr 3: 183.92 – 184.02 MbChr 16: 20.15 – 20.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance.

This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides.

Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercaptopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients.

Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.[7]

Interactive pathway map

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Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

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|alt=Fluorouracil (5-FU) Activity edit]]
Fluorouracil (5-FU) Activity edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000114770Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022822Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Allikmets R, Gerrard B, Hutchinson A, Dean M (Oct 1996). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Human Molecular Genetics. 5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID 8894702.
  6. ^ Belinsky MG, Bain LJ, Balsara BB, Testa JR, Kruh GD (Nov 1998). "Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins". Journal of the National Cancer Institute. 90 (22): 1735–41. doi:10.1093/jnci/90.22.1735. PMID 9827529.
  7. ^ a b "Entrez Gene: ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.