Canalicular multispecific organic anion transporter 2 is a protein that in humans is encoded by the ABCC3 gene.[4][5][6]

ABCC3
Identifiers
AliasesABCC3, ABC31, EST90757, MLP2, MOAT-D, MRP3, cMOAT2, ATP binding cassette subfamily C member 3
External IDsOMIM: 604323; MGI: 1923658; HomoloGene: 68364; GeneCards: ABCC3; OMA:ABCC3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001144070
NM_003786
NM_020037
NM_020038

NM_029600
NM_001363187
NM_001363189

RefSeq (protein)

NP_001137542
NP_003777

NP_083876
NP_001350116
NP_001350118

Location (UCSC)n/aChr 11: 94.23 – 94.28 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.[6]

ABCC3 is induced as a hepatoprotective response to a variety of pathologic liver conditions. The constitutive androstane receptor, pregnane X receptor and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) transcription factors are involved in mediating induction. A functional antioxidant response element in the 8th intron of the human ABCC3 gene appears responsible for Nrf2-mediated induction in response to oxidative stress.[7]

Interactive pathway map

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Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

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|alt=Fluorouracil (5-FU) Activity edit]]
Fluorouracil (5-FU) Activity edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

See also

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References

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  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020865Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Allikmets R, Gerrard B, Hutchinson A, Dean M (Feb 1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Hum Mol Genet. 5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID 8894702.
  5. ^ Belinsky MG, Bain LJ, Balsara BB, Testa JR, Kruh GD (Dec 1998). "Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins". J Natl Cancer Inst. 90 (22): 1735–41. doi:10.1093/jnci/90.22.1735. PMID 9827529.
  6. ^ a b "Entrez Gene: ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3".
  7. ^ Canet MJ, Merrell MD, Harder BG, Maher JM, Wu T, Lickteig AJ, Jackson JP, Zhang DD, Yamamoto M, Cherrington NJ (2014-10-27). "Identification of a Functional Antioxidant Response Element within the Eighth Intron of the Human ABCC3 Gene". Drug Metabolism and Disposition. 43 (1): 93–99. doi:10.1124/dmd.114.060103. PMC 4279086. PMID 25349122.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.