The Airbus A300 is a wide-body airliner.
A300 or A.300 may also refer to:
- A300 road, a main road in Great Britain
- Acorn Archimedes A300, a British home computer
- Aero A.300, a 1938 Czechoslovakian bomber aircraft
- Ansaldo A.300, a 1919 Italian general-purpose biplane aircraft
- Midland Highway (Victoria), a highway in Victoria, Australia bears the designation A300 for most of its route
- RFA Oakol (A300), a British fleet auxiliary vessel
- Weishi A300, a version of Chinese 300 mm rocket artillery
- AMD A300 platform, a system on a chip solution for AMD Ryzen processors
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