3beta-hydroxy-5alpha-steroid dehydrogenase

In enzymology, a 3β-hydroxy-5α-steroid dehydrogenase (EC 1.1.1.278) is an enzyme that catalyzes the chemical reaction

3β-hydroxy-5α-steroid dehydrogenase
Identifiers
EC no.1.1.1.278
CAS no.9015-81-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins
3β-hydroxy-5α-pregnane-20-one + NADP+ 5α-pregnan-3,20-dione + NADPH + H+

Thus, the two substrates of this enzyme are 3β-hydroxy-5α-pregnane-20-one (allopregnanolone) and NADP+, whereas its 3 products are 5α-pregnan-3,20-dione, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3β-hydroxy-5α-steroid:NADP+ 3-oxidoreductase.

References

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  • Lindemann P; Luckner M (1997). "Biosynthesis of pregnane derivatives in somatic embryos of Digitalis lanata". Phytochemistry. 46 (3): 507–513. doi:10.1016/S0031-9422(97)00315-4.
  • Warneck HM, Seitz HU (1990). "3 beta-hydroxysteroid oxidoreductase in suspension cultures of Digitalis lanata EHRH". Z. Naturforsch. C. 45 (9–10): 963–72. PMID 2291772.