3-hydroxyindolin-2-one monooxygenase (EC 1.14.13.139, BX4 (gene), CYP71C1 (gene)) is an enzyme with systematic name 3-hydroxyindolin-2-one,NAD(P)H:oxygen oxidoreductase (2-hydroxy-2H-1,4-benzoxazin-3(4H)-one-forming).[1][2][3] This enzyme catalyses the following chemical reaction
| 3-hydroxyindolin-2-one monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.13.139 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- 3-hydroxyindolin-2-one + NAD(P)H + H+ + O2 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)+ + H2O
3-hydroxyindolin-2-one monooxygenase is involved in the biosynthesis of protective and allelopathic benzoxazinoids in some plants.
References
edit- ^ Glawischnig E, Grün S, Frey M, Gierl A (March 1999). "Cytochrome P450 monooxygenases of DIBOA biosynthesis: specificity and conservation among grasses". Phytochemistry. 50 (6): 925–30. Bibcode:1999PChem..50..925G. doi:10.1016/s0031-9422(98)00318-5. PMID 10385992.
- ^ Frey M, Chomet P, Glawischnig E, Stettner C, Grün S, Winklmair A, Eisenreich W, Bacher A, Meeley RB, Briggs SP, Simcox K, Gierl A (August 1997). "Analysis of a chemical plant defense mechanism in grasses". Science. 277 (5326): 696–9. doi:10.1126/science.277.5326.696. PMID 9235894.
- ^ Spiteller P, Glawischnig E, Gierl A, Steglich W (June 2001). "Studies on the biosynthesis of 2-hydroxy-1,4-benzoxazin-3-one (HBOA) from 3-hydroxyindolin-2-one in Zea mays". Phytochemistry. 57 (3): 373–6. Bibcode:2001PChem..57..373S. doi:10.1016/s0031-9422(01)00037-1. PMID 11393516.
External links
edit- 3-hydroxyindolin-2-one+monooxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
