3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase (EC 1.14.14.12, HsaA) is an enzyme with systematic name 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione,FMNH2:oxygen oxidoreductase.[1] This enzyme catalyses the following chemical reaction:
3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase | |||||||||
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Identifiers | |||||||||
EC no. | 1.14.14.12 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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- 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H2O
This bacterial enzyme participates in the degradation of several steroids, including cholesterol and testosterone.
References
edit- ^ Dresen C, Lin LY, D'Angelo I, Tocheva EI, Strynadka N, Eltis LD (July 2010). "A flavin-dependent monooxygenase from Mycobacterium tuberculosis involved in cholesterol catabolism". The Journal of Biological Chemistry. 285 (29): 22264–75. doi:10.1074/jbc.M109.099028. PMC 2903365. PMID 20448045.
External links
edit- 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione+monooxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)