2nd Duke of Buckingham may refer to:
- Edmund Sheffield, 2nd Duke of Buckingham and Normanby (1716–1735), English nobleman
- George Villiers, 2nd Duke of Buckingham (1628–1687), English statesman
- Henry Stafford, 2nd Duke of Buckingham (1455–1483), Knight of the Garter
- Richard Temple-Grenville, 2nd Duke of Buckingham and Chandos (1797–1861), British politician
This disambiguation page lists articles associated with the title 2nd Duke of Buckingham.
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