This was the second of two editions of the tournament in the 2021 tennis season.[1] Marc-Andrea Hüsler and Zdeněk Kolář were the defending champions but only Kolář chose to defend his title, partnering Julien Cagnina. Kolář lost in the final to Raven Klaasen and Ruan Roelofse.
| Doubles | |
|---|---|
| 2021 Potchefstroom Open II | |
| Champions |  Raven Klaasen Ruan Roelofse |
| Runners-up |  Julien Cagnina Zdeněk Kolář |
| Score | 6–4, 6–4 |
This article relies largely or entirely on a single source. (September 2022) |
Klaasen and Roelofse won the title after defeating Cagnina and Kolář 6–4, 6–4 in the final.
Seeds edit
Raven Klaasen / Ruan Roelofse (champions)
Benjamin Bonzi / Tristan Lamasine (quarterfinals, withdrew)
Teymuraz Gabashvili / 
Mark Vervoort (semifinals)
Peter Polansky / Brayden Schnur (first round, withdrew)
Draw edit
Key edit
- Q = Qualifier
- WC = Wild card
- LL = Lucky loser
- Alt = Alternate
- SE = Special exempt
- PR = Protected ranking
- ITF = ITF entry
- JE = Junior exempt
- w/o = Walkover
- r = Retired
- d = Defaulted
- SR = Special ranking
| First round | Quarterfinals | Semifinals | Final | ||||||||||||||||||||||||
| 1 | R Klaasen R Roelofse
| 78 | 4 | [10] | |||||||||||||||||||||||
| V Kopřiva V Šafránek
| 6 | 6 | V Kopřiva V Šafránek
| 66 | 6 | [4] | |||||||||||||||||||||
 Milan Radojković Yan Sabanin
| 1 | 2 | 1 | R Klaasen R Roelofse
| 6 | 4 | [12] | ||||||||||||||||||||
| 3 | T Gabashvili M Vervoort
| 7 | 5 | [10] | 3 | T Gabashvili M Vervoort
| 3 | 6 | [10] | ||||||||||||||||||
 A Kadhe B Lock
| 5 | 7 | [7] | 3 | T Gabashvili M Vervoort
| w/o | |||||||||||||||||||||
| WC | Devin Badenhorst Luc Koenig
| 1 | 2 |  V Durasovic B Hassan
| |||||||||||||||||||||||
| V Durasovic B Hassan
| 6 | 6 | 1 | R Klaasen R Roelofse
| 6 | 6 | |||||||||||||||||||||
| WC | Vasilios Caripi Vaughn Hunter
| 4 | PR | J Cagnina Z Kolář
| 4 | 4 | |||||||||||||||||||||
P Krstin C-h Tseng
| 0r | WC | V Caripi V Hunter
| 6 | 6 | ||||||||||||||||||||||
| WC | Robbie Arends Khololwam Montsi
| w/o | WC | R Arends K Montsi
| 4 | 3 | |||||||||||||||||||||
| 4 |  P Polansky B Schnur
| WC | V Caripi V Hunter
| 4 | 2 | ||||||||||||||||||||||
 A Menéndez Maceiras L Miedler
| 5 | 6 | [9] | PR | J Cagnina Z Kolář
| 6 | 6 | ||||||||||||||||||||
| PR | J Cagnina Z Kolář
| 7 | 4 | [11] | PR | J Cagnina Z Kolář
| w/o | ||||||||||||||||||||
 G Blancaneaux J Clarke
| 2 | 3 | 2 | B Bonzi T Lamasine
| |||||||||||||||||||||||
| 2 | B Bonzi T Lamasine
| 6 | 6 | ||||||||||||||||||||||||