The 2010 Mercury Insurance Open was a women's tennis tournament played on outdoor hard courts. It was the first edition of the Southern California Open since the tournament left the tour in 2007. It was classified as one of the WTA Premier tournaments of the 2010 WTA Tour. It was played in San Diego, California, United States. Svetlana Kuznetsova won the singles title.
| 2010 Mercury Insurance Open | |
|---|---|
| Date | August 2–8 |
| Edition | 30th |
| Draw | 28S /16D |
| Prize money | $700,000 |
| Surface | Hard / outdoor |
| Location | San Diego, California, U.S. |
| Champions | |
| Singles | |
 Svetlana Kuznetsova | |
| Doubles | |
Maria Kirilenko /  Zheng Jie | |
Finals edit
Singles edit
Svetlana Kuznetsova defeated 
Agnieszka Radwańska, 6–4, 6–7(7–9), 6–3
- It was Kuznetsova's first title of the year and 13th of her career.
Doubles edit
Maria Kirilenko / Zheng Jie defeated 
Lisa Raymond / 
Rennae Stubbs, 6–4, 6–4
WTA entrants edit
Seeds edit
| Player | Nationality | Ranking* | Seed |
|---|---|---|---|
| Jelena Janković |  Serbia
|
2 | 1 |
| Samantha Stosur | Australia
|
5 | 2 |
| Vera Zvonareva | Russia
|
9 | 3 |
| Agnieszka Radwańska | Poland
|
11 | 4 |
| Flavia Pennetta |  Italy
|
12 | 5 |
| Marion Bartoli |  France
|
14 | 6 |
| Shahar Pe'er |  Israel
|
16 | 7 |
| Yanina Wickmayer |  Belgium
|
17 | 8 |
- Seedings are based on the rankings of July 26, 2010.
Other entrants edit
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
The following player received entry by a lucky loser spot: