Victoria Azarenka and Caroline Wozniacki were the defending champions, but they chose to compete in 2010 Dubai Tennis Championships instead.
Vania King and Michaëlla Krajicek won in the final 7–5, 6–2 against Bethanie Mattek-Sands and Meghann Shaughnessy.
| Doubles | |
|---|---|
| 2010 Regions Morgan Keegan Championships and the Cellular South Cup | |
| Champions |  Vania King Michaëlla Krajicek |
| Runners-up | Bethanie Mattek-Sands Meghann Shaughnessy |
| Score | 7–5, 6–2 |
| Draw | 16 |
| Seeds | 4 |
Seeds edit
Vladimíra Uhlířová / Renata Voráčová (first round)
Monica Niculescu / 
Riza Zalameda (semifinals)- Vania King /
Michaëlla Krajicek (champions) 
Maria Kondratieva / 
Sophie Lefèvre (first round)
Draw edit
Key edit
- Q = Qualifier
- WC = Wild card
- LL = Lucky loser
- Alt = Alternate
- SE = Special exempt
- PR = Protected ranking
- ITF = ITF entry
- JE = Junior exempt
- w/o = Walkover
- r = Retired
- d = Defaulted
- SR = Special ranking
Draws edit
| First round | Quarterfinals | Semifinals | Final | ||||||||||||||||||||||||
| 1 |  V Uhlířová R Voráčová
| 5 | 5 | ||||||||||||||||||||||||
 Y Fedossova K Lykina
| 7 | 7 | Y Fedossova K Lykina
| 3 | 0 | ||||||||||||||||||||||
| S Beltrame L Hradecká
| 2 | 5 | B Mattek-Sands M Shaughnessy
| 6 | 6 | ||||||||||||||||||||||
| B Mattek-Sands M Shaughnessy
| 6 | 7 | B Mattek-Sands M Shaughnessy
| 6 | 6 | ||||||||||||||||||||||
| 4 | M Kondratieva S Lefèvre
| 3 | 63 | M Oudin S Perry
| 2 | 2 | |||||||||||||||||||||
S Cohen-Aloro K Kučová
| 6 | 7 | S Cohen-Aloro K Kučová
| 2 | 3 | ||||||||||||||||||||||
 M Domachowska A Keothavong
| 3 | 4 | M Oudin S Perry
| 6 | 6 | ||||||||||||||||||||||
| M Oudin S Perry
| 6 | 6 | B Mattek-Sands M Shaughnessy
| 5 | 2 | ||||||||||||||||||||||
| WC | A Rus N Vaidišová
| 3 | 1 | 3 | V King M Krajicek
| 7 | 6 | ||||||||||||||||||||
 E Daniilidou J Wöhr
| 6 | 6 | E Daniilidou J Wöhr
| 4 | 63 | ||||||||||||||||||||||
| WC | C Collins M Ondeck
| 0 | 0 | 3 | V King M Krajicek
| 6 | 7 | ||||||||||||||||||||
| 3 | V King M Krajicek
| 6 | 6 | 3 | V King M Krajicek
| 6 | 6 | ||||||||||||||||||||
| L Granville L Osterloh
| 65 | 4 | 2 |  M Niculescu R Zalameda
| 1 | 4 | |||||||||||||||||||||
| K Barrois K Wörle
| 7 | 6 | K Barrois K Wörle
| 5 | 6 | [8] | |||||||||||||||||||||
| A Glatch A Haynes
| 6 | 4 | 6 | 2 | M Niculescu R Zalameda
| 7 | 4 | [10] | |||||||||||||||||||
| 2 | M Niculescu R Zalameda
| 1 | 6 | [10] | |||||||||||||||||||||||