Eric Butorac and Jamie Murray were the defending champions. They were both present but did not compete together.
Butorac partnered with Todd Perry, but lost in the first round to Scott Lipsky and David Martin.
Murray partnered with Max Mirnyi, but lost in the first round to Thomas Johansson and Robert Lindstedt.
| Doubles | |
|---|---|
| 2008 Regions Morgan Keegan Championships and the Cellular South Cup | |
| Champions |  Mahesh Bhupathi Mark Knowles |
| Runners-up |  Sanchai Ratiwatana Sonchat Ratiwatana |
| Score | 7–6(7–5), 6–2 |
Mahesh Bhupathi and Mark Knowles won in the final 7–6(7–5), 6–2, against Sanchai Ratiwatana and Sonchat Ratiwatana.
Seeds edit
Mahesh Bhupathi / 
Mark Knowles (champions)
Jonas Björkman / 
Kevin Ullyett (first round)
Max Mirnyi / 
Jamie Murray (first round)
Marcelo Melo / André Sá (semifinals)
Draw edit
Key edit
- Q = Qualifier
- WC = Wild card
- LL = Lucky loser
- Alt = Alternate
- SE = Special exempt
- PR = Protected ranking
- ITF = ITF entry
- JE = Junior exempt
- w/o = Walkover
- r = Retired
- d = Defaulted
- SR = Special ranking
Draw edit
| First round | Quarterfinals | Semifinals | Final | ||||||||||||||||||||||||
| 1 | M Bhupathi M Knowles
| 6 | 6 | ||||||||||||||||||||||||
| WC |  J Isner D Young
| 4 | 2 | 1 | M Bhupathi M Knowles
| 6 | 6 | ||||||||||||||||||||
 I Kunitsyn J Thomas
| 7 | 6 | I Kunitsyn J Thomas
| 3 | 2 | ||||||||||||||||||||||
R Bopanna D Sela
| 5 | 4 | 1 | M Bhupathi M Knowles
| 711 | 6 | |||||||||||||||||||||
| 3 |  M Mirnyi J Murray
| 6 | 4 | [7] |  C Haggard J Melzer
| 69 | 2 | ||||||||||||||||||||
 T Johansson R Lindstedt
| 1 | 6 | [10] | T Johansson R Lindstedt
| 63 | 6 | [6] | ||||||||||||||||||||
| WC | A Kuznetsov R Sweeting
| 4 | 6 | [10] | C Haggard J Melzer
| 77 | 3 | [10] | |||||||||||||||||||
| C Haggard J Melzer
| 7 | 4 | [12] | 1 | M Bhupathi M Knowles
| 77 | 6 | ||||||||||||||||||||
| R Ram B Reynolds
| 6 | 0 | [10] | S Ratiwatana S Ratiwatana
| 65 | 2 | |||||||||||||||||||||
| S Querrey V Spadea
| 3 | 6 | [12] | S Querrey V Spadea
| 1 | 4 | |||||||||||||||||||||
M Safin R Štěpánek
| 4 |  M Melo A Sá
| 6 | 6 | |||||||||||||||||||||||
| 4 | M Melo A Sá
| w/o | 4 | M Melo A Sá
| 3 | 6 | [13] | ||||||||||||||||||||
E Butorac T Perry
| 62 | 6 | [7] | S Ratiwatana S Ratiwatana
| 6 | 3 | [15] | ||||||||||||||||||||
| S Lipsky D Martin
| 77 | 3 | [10] | S Lipsky D Martin
| 4 | 5 | |||||||||||||||||||||
| S Ratiwatana S Ratiwatana
| 3 | 77 | [11] | S Ratiwatana S Ratiwatana
| 6 | 7 | |||||||||||||||||||||
| 2 | J Björkman K Ullyett
| 6 | 64 | [9] | |||||||||||||||||||||||