Laura Granville and Abigail Spears were the defending champions, but had different outcomes. While Granville did not compete this year, Spears partnered with Carly Gullickson and lost in first round to Chan Chin-wei and Tetiana Luzhanska.
| Doubles | |
|---|---|
| 2006 Western & Southern Financial Group Women's Open | |
| Champions |  Maria Elena Camerin Gisela Dulko |
| Runners-up |  Marta Domachowska Sania Mirza |
| Score | 6–4, 3–6, 6–2 |
| Draw | 15 |
| Seeds | 4 |
Maria Elena Camerin and Gisela Dulko won the title, defeating Marta Domachowska and Sania Mirza 6–4, 3–6, 6–2 in the final. It was the 3rd and final title for Camerin and the 6th title for Dulko, in their respective careers.
Seeds edit
Maria Elena Camerin / 
Gisela Dulko (champions)
Bethanie Mattek/ Mashona Washington(withdrew due to a left knee injury on Washington)
Marta Domachowska / 
Sania Mirza (final)- Carly Gullickson / Abigail Spears (first round)
Emma Laine / 
Hana Šromová (semifinals)
Draw edit
Key edit
- Q = Qualifier
- WC = Wild card
- LL = Lucky loser
- Alt = Alternate
- SE = Special exempt
- PR = Protected ranking
- ITF = ITF entry
- JE = Junior exempt
- w/o = Walkover
- r = Retired
- d = Defaulted
- SR = Special ranking
| First round | Quarterfinals | Semifinals | Final | ||||||||||||||||||||||||
| 1 | MC Camerin G Dulko
| 0 | 6 | 6 | |||||||||||||||||||||||
 M Drake S Uberoi
| 6 | 1 | 3 | 1 | MC Camerin G Dulko
| 6 | 6 | ||||||||||||||||||||
 R de los Ríos J Janković
| 6 | 6 | R de los Ríos J Janković
| 4 | 4 | ||||||||||||||||||||||
| WC |  Angela Farley-Wilson Keri Preng
| 2 | 0 | 1 | MC Camerin G Dulko
| 6 | 6 | ||||||||||||||||||||
| 5 |  E Laine H Šromová
| 6 | 6 | 5 | E Laine H Šromová
| 2 | 2 | ||||||||||||||||||||
| S Fonseca T Snyder
| 3 | 1 | 5 | E Laine H Šromová
| 3 | 6 | 6 | ||||||||||||||||||||
| J Kirkland L Osterloh
| 2 | 3 |  A Amanmuradova O Savchuk
| 6 | 3 | 3 | |||||||||||||||||||||
| A Amanmuradova O Savchuk
| 6 | 6 | 1 | MC Camerin G Dulko
| 6 | 3 | 6 | ||||||||||||||||||||
| 3 | M Domachowska S Mirza
| 4 | 6 | 2 | |||||||||||||||||||||||
 A Keothavong A Kudryavtseva
| 2 | 3 | |||||||||||||||||||||||||
 C-w Chan T Luzhanska
| 6 | 6 | C-w Chan T Luzhanska
| 6 | 6 | ||||||||||||||||||||||
| 4 | C Gullickson A Spears
| 4 | 3 | C-w Chan T Luzhanska
| 0 | 1 | |||||||||||||||||||||
V Bardina S Devidze
| 3 | 6 | 1 | 3 | M Domachowska S Mirza
| 6 | 6 | ||||||||||||||||||||
V Lepchenko M Yuan
| 6 | 3 | 6 | V Lepchenko M Yuan
| 4 | 7 | 63 | ||||||||||||||||||||
 N Grandin M Sequera
| 4 | 3 | 3 | M Domachowska S Mirza
| 6 | 5 | 77 | ||||||||||||||||||||
| 3 | M Domachowska S Mirza
| 6 | 6 | ||||||||||||||||||||||||