2-Methyl-2-propyl-1,3-propanediol (MPP) is a simple alkyl diol which has sedative, anticonvulsant and muscle relaxant effects.
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Clinical data | |
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Other names | 2,2-Bis(hydroxymethyl)pentane |
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ECHA InfoCard | 100.001.000 |
Chemical and physical data | |
Formula | C7H16O2 |
Molar mass | 132.203 g·mol−1 |
3D model (JSmol) | |
Melting point | 56–59 °C (133–138 °F) |
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Precursor/metabolite
editIt is both a synthetic precursor to, and an active metabolite of tranquilizers and other derivatives:[1][2][3][4]
See also
editReferences
edit- ^ Wang G, Lu Q (October 2013). "A nitrate ester of sedative alkyl alcohol improves muscle function and structure in a murine model of Duchenne muscular dystrophy". Molecular Pharmaceutics. 10 (10): 3862–70. doi:10.1021/mp400310r. PMID 23924275.
- ^ Yale HL, Pribyl EJ, Braker W, Bergeim FH, Lott WA (August 1950). "Muscle-relaxing Compounds Similar to 3-(o-Toloxy)-1, 2-propanediol. 1 I. Aromatic Ethers of Polyhydroxy Alcohols and Related Compounds". Journal of the American Chemical Society. 72 (8): 3710–6. doi:10.1021/ja01164a108.
- ^ JP 09031000, Kato K, Tsukamoto K, "2-(2-Alkenyl)-1,3-propanediols and preparation of 2,2-disubstituted-1,3-propanediols", issued 1997
- ^ Kaithal A, Hölscher M, Leitner W (October 2018). "Catalytic Hydrogenation of Cyclic Carbonates using Manganese Complexes". Angewandte Chemie International Edition in English. 57 (41): 13449–13453. doi:10.1002/anie.201808676. PMC 6221167. PMID 30134081.