The Duke of Newcastle is a title that has been created thrice in British history. The first Duke may refer to:
- William Cavendish, 1st Duke of Newcastle (1592–1676), English polymath and aristocrat
- John Holles, 1st Duke of Newcastle (1662–1711), English peer
- Thomas Pelham-Holles, 1st Duke of Newcastle (1693–1768), British Whig statesman
This disambiguation page lists articles associated with the title 1st Duke of Newcastle.
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