The Coupe de France 1980–81 was its 64th edition. It was won by SC Bastia which defeated AS Saint-Étienne in the Final.
| Tournament details | |
|---|---|
| Country |  France |
Round of 16 edit
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
|---|---|---|---|---|
| SEC Bastia (D1) | 3–2 | AS Monaco (D1) | 2–0 | 1–2 |
| FC Nantes (D1) | 5–10 | Girondins de Bordeaux (D1) | 1–4 | 4–6 |
| AS Nancy (D1) | 3–4 | AS Saint-Étienne (D1) | 2–1 | 1–3 |
| LB Châteauroux (D2) | 1–2 | Lille OSC (D1) | 1–0 | 0–2 |
| Le Havre AC (D2) | 1–2 | RC Lens (D1) | 1–0 | 0–2 |
| FC Metz (D1) | 2–2 (a) | Montpellier HSC (D2) | 2–1 | 0–1 |
| RC Strasbourg (D1) | 3–2 | AS Angoulême (D2) | 2–0 | 1–2 |
| Thionville FC (D2) | 2–5 | FC Martigues (D2) | 2–2 | 0–3 |
Quarter-finals edit
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
|---|---|---|---|---|
| RC Lens (D1) | 3–2 | Lille OSC (D1) | 3–1 | 0–1 |
| Girondins de Bordeaux (D1) | 1–9 | RC Strasbourg (D1) | 1–5 | 0–4 |
| AS Saint-Étienne (D1) | 3–2 | Montpellier HSC (D2) | 2–1 | 1–1 |
| FC Martigues (D2) | 3–5 | SEC Bastia (D1) | 3–0 | 0–5 |
Semi-finals edit
First leg edit
| Saint-Étienne (1) | 2–1 | Strasbourg (1) |
|---|---|---|
Bellus  32'Zanon 67' |
Report | Piasecki 16' |
Second leg edit
Bastia won 3–1 on aggregate.
| Strasbourg (1) | 1–1 | Saint-Étienne (1) |
|---|---|---|
| Decastel 77' |
Report | Perez 88' |
Saint-Étienne won 3–2 on aggregate.