Wikipedia:United States Education Program/Courses/JHU MolBio Ogg 2013/Group 81A

Group 81A edit

This is the Wikipedia page for 410.602 Molecular Biology, Spring, 2013, group 81A. This group will be working on the article Silent mutation.

Use the talk page here to collaborate as a group, when learning to use and navigate Wikipedia, assessing articles, or for any other topic.

Use this page (not the talk page) for article assessments; rationale for selecting an article; etc.

Please create a new section here for each of those assignments.

Initial article assessments from Awotawa1 edit

Silent mutation article

The information that is given is a good base from which to begin expanding. The initial information given is somewhat well-written and has some organization. However, the article in its current state only gives a basic description of the overall topic. Several areas can and should be expanded to include more meaningful content for readers. Basically, the article as is provides an introduction to the topic. Good references are used thus far, but further consistent formatting of references is needed. It appears that not all of the references given are used in inline citations within the current portions of the article.

References:

Sauna ZE, Kimchi-Sarfaty C. Understanding the contribution of synonymous mutations to human disease. Nat Rev Genet. 2011 Aug 31;12(10):683-91. doi: 10.1038/nrg3051. Review. PMID 21878961

Czech A, Fedyunin I, Zhang G, Ignatova Z. Silent mutations in sight: co-variations in tRNA abundance as a key to unravel consequences of silent mutations. Mol Biosyst. 2010 Oct;6(10):1767-72. doi: 10.1039/c004796c. Epub 2010 Jul 9. Review. PMID 20617253

Chromosomal duplication (gene duplication) article

This article is broad in spectrum and should be more highly focused and better organized. Some language used in the text doesn't sound neutral, needs further citation, or should be stated in more of a scientific tone rather than a casual tone. Good images are used, and a variety of references have been used thus far. Some sections are more developed than others. Some of the subtopics under the main article topic are merely definitions or brief introductions to the subtopics, while other subtopics are more developed and give more information to the reader.

References:

Eirín-López JM, Rebordinos L, Rooney AP, Rozas J. The birth-and-death evolution of multigene families revisited. Genome Dyn. 2010;7:170-96. doi: 10.1159/000337119. Epub 2012 Jun 25. Review. PMID 22759819

Crotwell PL, Hoyme HE. Advances in whole-genome genetic testing: from chromosomes to microarrays. Curr Probl Pediatr Adolesc Health Care. 2012 Mar;42(3):47-73. doi: 10.1016/j.cppeds.2011.10.004. Review. PMID 22325474

Hollox EJ. The challenges of studying complex and dynamic regions of the human genome. Methods Mol Biol. 2012;838:187-207. doi: 10.1007/978-1-61779-507-7_9. Review. PMID 22228013 Awotawa1 (talk) 02:02, 28 February 2013 (UTC)[reply]

Initial Article Assessments from tbrownc1 edit

Fluorescent tag

This article needs a lot more information. The process of fluorescent tagging should be covered in depth. Then the different types of fluorescent tags should be described with images. There are no references for the information in the article. There are a lot of different subtopics that could be covered within fluorescent tag to make it a well-rounded informative article.

References:

Jung D, Min K, Jung J, Jang W, Kwon Y (January 2013). "Chemical biology-based approaches on fluorescent labeling of proteins in live cells". Mol Biosyst. doi:10.1039/c2mb25422k. PMID 23318293.

Ma L, Su M, Li T, Wang Z (January 2013). "Microarray-based fluorescence assay of endonuclease functionality and inhibition". Analyst. 138 (4): 1048–52. doi:10.1039/c2an36638j. PMID 23282850.

Nitrogenous base

This article has good information included but once again a lot of the topics can be expanded more. For the amount of information given there are not many sources. Mechanisms of nitrogenous bases could be included, along with images.

References:

Bell DC, Thomas WK, Murtagh KM, et al. (October 2012). "DNA base identification by electron microscopy". Microsc. Microanal. 18 (5): 1049–53. doi:10.1017/S1431927612012615. PMID 23046798.

Fornili A, Sironi M, Degano M (June 2007). "Accurate description of nitrogenous base flexibility in classical molecular dynamics simulations of nucleotides bound to proteins". J Phys Chem B. 111 (23): 6297–302. doi:10.1021/jp0713357. PMID 17508739.

Tbrownc1 (talk) 04:12, 28 February 2013 (UTC)[reply]

Article selection rationale edit

Group 81A has chosen to develop the article Silent mutations. The topic is of interest to the individual group members, and we deem that it is of high importance within the scopes of molecular and cell biology and genetics. The article in its current state has a lot of potential to be developed into a more detailed and complete article. The article already has the framework of an introduction and several subtopics. In addition to expanding and refining the introduction, the existing subtopics should be developed further, especially the subtopic pertaining to examples of the roles of silent mutations in disease. During the course of organizing and expanding the article, other subtopics will be added to provide the reader with more comprehensive information on the topic. Our group has found some reliable references to use in the expansion of the article in addition to the references already set forth by the original author, which can be mined further for added pertinent information.

Unit 9 Progress Report edit

Altered headings of sections within the article

Created "Silent Mutations and the Genetic Code" section of the article
- Added citations and references from credible sources

Created "Structural Consequences of Silent Mutations" section of the article
- Added subsections for primary, secondary, and tertiary protein structure
- Added citations and references from credible sources

(Most contributions were prose)

Tbrownc1 (talk) 03:56, 5 April 2013 (UTC)[reply]

Final Progress Report edit

Edited lead section of article

Added "Different Types of Mutations" image to show an example of a silent mutation.

Edited "Silent mutations and the genetic code" section of the article

Edited "Transfer RNA" section

Edited "Structural consequences of silent mutations" section

Added a specific example of silent mutations

Edited and changed last section's title to "Research and clinical applications"

Organized reference section

Tbrownc1 (talk) 02:06, 10 May 2013 (UTC)[reply]