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User:Synpath/sandbox

< User:Synpath

Template Test

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infobox copied from Vitamin E to test adding ImageClass parameter

Synpath/sandbox
Drug class
 
The RRR alpha-tocopherol form of vitamin E
Class identifiers
UseVitamin E deficiency, antioxidant
ATC codeA11HA03
Biological targetReactive oxygen species
Clinical data
Drugs.comMedFacts Natural Products
External links
MeSHD014810
Legal status

infobox copied from Morphine

Synpath/sandbox
 
 
Clinical data
Pronunciation/ˈmɔːrfiːn/
Trade namesStatex, MS Contin, Oramorph, others[1]
AHFS/Drugs.comMonograph
MedlinePlusa682133
License data
Pregnancy
category
Dependence
liability		High
Addiction
liability		High[3]
Routes of
administration		Inhalation (smoking), insufflation (snorting), by mouth, rectal, subcutaneous, intramuscular, intravenous, epidural, intrathecal
Drug classOpiate
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability20–40% (by mouth), 36–71% (rectally),[9] 100% (IV/IM)
Protein binding30–40%
MetabolismLiver: UGT2B7
Metabolites• Morphine-3-glucuronide (90%)
• Morphine-6-glucuronide (10%)
Onset of action5 minutes (IV), 15 minutes (IM),[10] 20 minutes (PO)[11]
Elimination half-life2–3 hours
Duration of action3–7 hours[12][13]
ExcretionKidney 90%, bile duct 10%
Identifiers
  • (4R,4aR,7S,7aR,12bS)-3-Methyl-2,3,4,4a,7,7a-hexahydro-1H-4,12-methano[1]benzofuro[3,2-e]isoquinoline-7,9-diol
CAS Number
  • 57-27-2  Y
    64-31-3 (neutral sulfate),
    52-26-6 (hydrochloride)
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB ligand
Chemical and physical data
FormulaC17H19NO3
Molar mass285.343 g·mol−1
3D model (JSmol)
Solubility in waterHCl & sulf.: 60
  • CN1CC[C@]23C4=C5C=CC(O)=C4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5
  • InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1  Y
  • Key:BQJCRHHNABKAKU-KBQPJGBKSA-N  Y
  (verify)

Misc

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The RCSB Molecule(s) of the Month are bacterial nanowires like PDB: 7qv7, hydrogen-dependent carbon dioxide reductase (HDCR) -> https://pdb101.rcsb.org/motm/290

  • I think these should be added to Nanowire as a separate section summarizing their function and structures and hatnote to the main article Bacterial nanowires where there is no current coverage of their structure.
  • Also consider adding PDB 7xkm to Molecular wire

Natural Nanowires

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Template Char Angbr "M"
Em space   ⟨ ⟩ M M
En space   ⟨ ⟩ M M
nb space   ⟨ ⟩ M M
thin space   ⟨ ⟩ M M
hair space   ⟨ ⟩ M M
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portals: GenomeNet EBI EMBNet

programs: PSAlign PRRN/PRRP CHAOS/DIALIGN M-COFFEE MergeAlign POA SAM MEME/MAST EDNA TCS

  1. ^ Cite error: The named reference drugs.com-page was invoked but never defined (see the help page).
  2. ^ "Morphine Use During Pregnancy". Drugs.com. 14 October 2019. Retrieved 21 August 2020.
  3. ^ Bonewit-West K, Hunt SA, Applegate E (2012). Today's Medical Assistant: Clinical and Administrative Procedures. Elsevier Health Sciences. p. 571. ISBN 978-1-4557-0150-6.
  4. ^ "Morphine Product information". Health Canada. 9 August 2005. Retrieved 4 April 2024.
  5. ^ Cite error: The named reference Black's was invoked but never defined (see the help page).
  6. ^ "Sevredol Summary of Product Characteristics (SmPC)". (emc). 13 February 2024. Retrieved 20 February 2024.
  7. ^ "MS Contin- morphine sulfate tablet". DailyMed. 27 December 2023. Retrieved 20 February 2024.
  8. ^ "Modified-released oral opioids". European Medicines Agency. 18 November 2010. Retrieved 20 February 2024.
  9. ^ Jonsson T, Christensen CB, Jordening H, Frølund C (April 1988). "The bioavailability of rectally administered morphine". Pharmacology & Toxicology. 62 (4): 203–5. doi:10.1111/j.1600-0773.1988.tb01872.x. PMID 3387374.
  10. ^ Whimster F (1997). Cambridge textbook of accident and emergency medicine. Cambridge: Cambridge University Press. p. 191. ISBN 978-0-521-43379-2. Archived from the original on 8 September 2017.
  11. ^ Liben S (2012). Oxford textbook of palliative care for children (2 ed.). Oxford: Oxford University Press. p. 240. ISBN 978-0-19-959510-5. Archived from the original on 8 September 2017.
  12. ^ Cite error: The named reference AHFS2015 was invoked but never defined (see the help page).
  13. ^ Cite error: The named reference Rockwood2009 was invoked but never defined (see the help page).
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